Our ingredients are backed by science.
Cannabis is a wonderful plant. It has been used by humans for thousands of years, and for good reasons.
But let’s face it. For most enthusiasts, cannabis also has its drawbacks.
Many of us experience grogginess the day after consuming cannabis. It’s harder to concentrate and think clearly. We feel fatigued. Getting things done is more difficult than usual.
Potion was carefully formulated to support your body's normal metabolism the day after consuming cannabis. It helps replenish lost vitamins and neurotransmitters, and it maintains a healthy endocannabinoid system.
Potion is a dietary supplement made with the following natural ingredients: L-Theanine, Rhodiola Rosea, L-Tyrosine, Acetyl-L-Carnitine, Vitamins B6, B9, and B12.
They work with your body’s natural chemistry to help you feel great the day after consuming cannabis.
Feeling blah the day after eating that brownie?
Can’t really concentrate and get things done?
Here’s how Potion's unique combination of ingredients can help:
L-Theanine is an amino acid primarily found in green tea leaves. It has been shown to increase focus and mental clarity  in as little as 30 minutes . It also induces calm and relaxation without drowsiness .
When we consume cannabis, it creates a temporary increase in dopamine, the “happy neurotransmitter”. That’s where the "high" comes from, along with that groggy feeling the next day.
THC binds to the CB1 receptor and inhibits the production of GABA. GABA is a neurotransmitter that helps regulate the production of dopamine: it is the “STOP” signal for dopamine production.
So right after consuming cannabis, the “STOP” signal for dopamine production is decreased. The dopamine neuron runs free, and dopamine levels are increased.
But the brain is a fine-tuning instrument that always seeks balance. So the day after consuming cannabis, the brain tries to correct the imbalance and dopamine levels are low. That's in part what creates that dull, groggy feeling the next day.
L-Theanine helps your body restore optimal levels of dopamine. It has been shown to promote the release of dopamine  and GABA , helping you feel more focused and clear-headed, ultimately reducing the effects of next-day grogginess.
Studies have shown that L-Theanine also promotes alpha brain wave production and optimal brain cell function , helping your brain be organized, calm and focused the next day.
Rhodiola Rosea is a natural plant that grows in cold, mountainous regions.
Research shows that it promotes mental and physical energy . It is also believed to help maintain memory, focus, mental clarity, and cognitive acuity [7, 8, 9].
As we have seen above, your body tries to correct the temporary chemical imbalance that results from consuming cannabis, by lowering dopamine levels the next day.
Rhodiola Rosea helps your body restore balance and neutralize next-day grogginess by bringing dopamine levels back to normal.
Specifically, Rhodiola Rosea appears to inhibit MAO enzymes  and might also inhibit the COMT enzyme , which are both responsible for the chemical breakdown of dopamine in the brain .
Rhodiola Rosea is believed to help support optimal dopamine levels through inhibition of degradation enzymes and facilitation of neurotransmitter support in the brain, helping you think clearly and stay energized on the day after consuming cannabis.
L-Tyrosine is an important amino acid that is naturally produced by the body. It is found in many foods (cheese, especially).
Studies show that L-Tyrosine may help maintain healthy memory function and promote clear thinking and attention during stressful situations [13, 14].
The next-day grogginess that you experience after consuming cannabis is perceived as a stressful situation by your body. Stress has been shown to negatively and temporarily affect your reasoning, memory, attention and knowledge by decreasing important neurotransmitters [15, 16].
L-Tyrosine is a precursor to these key neurotransmitters, including dopamine. It increases plasma dopamine levels and helps maintain healthy levels of dopamine.
In fact, a number of studies have shown that L-Tyrosine can help maintain cognitive performance and clear thinking when people are exposed to stressful situations [17, 18], helping you maintain your ability to focus, memorize, and think clearly the day after consuming cannabis.
Studies also show that L-Tyrosine can attenuate the decrease in cognitive performance that is associated with poor sleep quality . Cannabis has been shown to affect sleep quality, which is part of the reason why we feel groggy the next day .
Carnitine is an amino acid that the body produces naturally. It is found in nearly all cells of the body.
Acetyl-L-Carnitine is a specific type of Carnitine that helps you feel great and be productive the day after consuming cannabis, by helping your body maintain general brain function and support optimal memory function.
Specifically, studies have shown that Acetyl-L-Carnitine helps improve mental clarity and energy [21, 22], increases focus and supports healthy memory function .
THC binds to the CB1 receptor when we consume cannabis. CB1 is responsible for the “high” associated with cannabis.
But when cannabis is consumed frequently, CB1 goes through a process called "internalization". It means that it withdraws into the cell, and becomes temporarily inactive.
Other receptors associated with CB1 will follow and be internalized into the cell as well, most notably the NMDA receptor.
This internalization of the NMDA receptor is important, because an overall decrease in NMDA receptors has been known to temporarily compromise learning and memory .
That’s how cannabis can make it harder to remember things in the short term. It’s the same feeling that you get when you check your watch, only to realize immediately after that you don’t remember the time. This effect does not seem to cause any long lasting memory problems. It is only temporary. But it is an issue when we have to get things done the next day.
Studies have found that Acetyl-L-Carnitine supports learning and memory by increasing the number of NMDA receptors in the whole brain , ultimately supporting healthy memory function and clear thinking the next day.
Vitamins B6, B9, and B12
Vitamins B6, B9, and B12 are naturally occurring. They have been shown to play an important role in maintaining optimal levels of neurotransmitters in the brain, as well as helping your body produce energy .
B vitamins play a role in maintaining healthy cognitive function by aiding the biosynthesis of important neurotransmitters, including those that are depleted on the day after consuming cannabis, such as dopamine and GABA .
B vitamins may also help maintain normal levels of homocysteine . Studies have shown that high levels of homocysteine may impair cognitive functions , and that cannabis may both increase levels of homocysteine and lower levels of vitamin B12 . Supplementing with vitamins B6, B9, and B12 may consequently attenuate these effects and make you feel better the next day.
Potion is manufactured in an FDA regulated facility and made in the USA. It only contains safe, premium ingredients. We are our own customer, and we take great pride in making the most safe and effective product possible.
- T. Giesbrecht,J.A. Rycroft,M.J. Rowson &E.A. De Bruin. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. An International Journal on Nutrition, Diet and Nervous System. (2013)
- Russ Mason, M.S. 200 mg of Zen L-Theanine Boosts Alpha Waves, Promotes Alert Relaxation. ALTERNATIVE & COMPLEMENTARY THERAPIES. (2001)
- Anna C Nobre PhD, Anling Rao PhD and Gail N Owen PhD. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. (2008)
- Hidehiko Yokogoshi, Miki Kobayashi, Mikiko Mochizuki & Takehiko Terashima. Effect of Theanine, r-Glutamylethylamide, on Brain Monoamines and Striatal Dopamine Release in Conscious Rats. Neurochemical Research volume 23, pages 667–673. (1998)
- Kimura R, Murata T. Influence of alkylamides of glutamic acid and related compounds on the central nervous system. I. Central depressant effect of theanine. Chem Pharm Bull (Tokyo). (1971)
- V Darbinyan 1, A Kteyan, A Panossian, E Gabrielian, G Wikman, H Wagner. Rhodiola rosea in stress induced fatigue--a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. PMID: 11081987 DOI: 10.1016/S0944-7113(00)80055-0. (2000)
- Damianka P. Getova & Anita S. Mihaylova. Effects of Rhodiola rosea extract on passive avoidance tests in rats. Central European Journal of Medicine volume 8, pages 176–181. (2013)
- Katrien De Bock 1, Bert O Eijnde, Monique Ramaekers, Peter Hespel. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab. Jun;14(3):298-307. doi: 10.1123/ijsnem.14.3.298. (2004)
- Erik M Olsson 1, Bo von Schéele, Alexander G Panossian. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress-related fatigue. Planta Med. (2009)
- van Diermen D, et al. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. (2009)
- Blum K, et al. Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis. Med Hypotheses (2007)
- John P M Finberg. Inhibitors of MAO-B and COMT: their effects on brain dopamine levels and uses in Parkinson's disease. J Neural Transm (Vienna). (2019)
- L E Banderet 1, H R Lieberman. Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull . (1989)
- Caroline R Mahoney 1, John Castellani, F Matthew Kramer, Andrew Young, Harris R Lieberman. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiol Behav. (2007)
- Anil Kumar, Puneet Rinwa, Gurleen Kaur, and Lalit Machawal. Stress: Neurobiology, consequences and management. J Pharm Bioallied Sci. (2013)
- Francisco Mora 1, Gregorio Segovia, Alberto Del Arco, Marta de Blas, Pedro Garrido. Stress, neurotransmitters, corticosterone and body-brain integration. Brain Res. (2012)
- Deijen JB, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res. Bull. (1994).
- Deijen JB, Wientjes CJ, Vullinghs HF, Cloin PA, Langefeld JJ. Tyrosine improves cognitive performance and reduces blood pressure in cadets after one week of a combat training course. Brain Res. Bull. (1999).
- D F Neri, D Wiegmann, R R Stanny, S A Shappell, A McCardie, D L McKay. The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med . (1995)
- Kimberly A Babson, James Sottile, Danielle Morabito. Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. (2017)
- Michele Malaguarnera, Maria Pia Gargante, Erika Cristaldi, Valentina Colonna, Masa Messano, Aleardo Koverech, Sergio Neri, Marco Vacante, Lisa Cammalleri, Massimo Motta. Acetyl L-carnitine (ALC) treatment in elderly patients with fatigue. Arch Gerontol Geriatr. (2008).
- Miroslav Cuturic, Ruth K Abramson, Robert R Moran, James W Hardin. Clinical outcomes and low-dose levocarnitine supplementation in psychiatric inpatients with documented hypocarnitinemia: a retrospective chart review. J Psychiatr Pract. (2010)
- Satoru Kobayashi, Machiko Iwamoto, Kazuo Kon, Hatsue Waki, Susumu Ando, Yasukazu Tanaka. Acetyl-L-carnitine improves aged brain function. Geriatr Gerontol Int. (2010).
- Fei Li, M.D., Ph.D. and Joe Z. Tsien, Ph.D. Memory and the NMDA Receptors. N Engl J Med. (2009).
- M Castorina, A M Ambrosini, L Pacific, M T Ramacci, L Angelucci. Age-dependent loss of NMDA receptors in hippocampus, striatum, and frontal cortex of the rat: prevention by acetyl-L-carnitine. Neurochem Res. (1994).
- Gustav Schellack, Pamela Harirari, Sefako Makgatho. B-complex vitamin deficiency and supplementation. South African Pharmaceutical Journal. (2015).
- David O. Kennedy. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients. (2016).
- Mackey A, Davis S, Gregory J. Vitamin B6. In: Shils M, Shike M, Ross A, Caballero B, Cousins R, eds. Modern Nutrition in Health and Disease. 10th ed. Baltimore, MD: Lippincott Williams & Wilkins. (2005).
- Angeles Garcia and Katherine Zanibbi. Homocysteine and cognitive function in elderly people. CMAJ. (2004).
- Blazej Misiak, Dorota Frydecka, Ryszard Slezak, Patryk Piotrowski, and Andrzej Kiejna. Elevated homocysteine level in first-episode schizophrenia patients—the relevance of family history of schizophrenia and lifetime diagnosis of cannabis abuse. Metab Brain Dis. (2014).
None of the statements on our website have been evaluated by the Food and Drug Administration (FDA). Potion is not intended to diagnose, treat, cure or prevent any disease. We do not encourage anyone to consume cannabis. If you do consume cannabis, please do so responsibly, and never consume cannabis if it is illegal where you live. Consult a physician before taking our supplement if you are on medication, pregnant, breastfeeding or have a known medical condition.